Gas Relief Capsules

Active Ingredients: Simethicone

Gas Relief Capsules (Simethicone) are used to relieve symptoms caused by excessive gas (flatulence) in the stomach and intestines. It helps relieve symptoms like painful pressure, fullness, and bloating. Simethicone is also used to help relieve symptoms associated with irritable bowel syndrome (IBS). Simethicone has been in use since the 1940s but was granted FDA approval in 1952.

Simethicone works quickly, typically within 30 minutes, and is considered safe for use by babies, children, and adults.

Simethicone is a compound formed from a mixture of polydimethylsiloxane and hydrated silica gel. It is classified as an antiflatulent or a gastrointestinal agent. Simethicone works by changing the surface pressure of the gas bubbles in the digestive system. It decreases the surface tension. This action causes them to clump together and pass through the system more easily. It leads to their expulsion. Its duration of action is short, and it is given as needed. It has a wide therapeutic index because it is not systemically absorbed. This drug allows the gas to exit the body more easily.

AdvaCare Pharma is a manufacturer and supplier of Simethicone Softgel Capsules. Every part of our supply chain is thoroughly vetted to ensure it meets health, safety, and environmental standards. This drug is produced in our GMP-certified facilities in China, India, and the USA.

AdvaCare Pharma is a GMP manufacturer of Gas Relief Capsules. Our strategically located facilities ensure that our company has complete control over the supply chain, meaning higher quality products and lower costs for production, transportation and importation. Over the past 20 years, we have built a solid reputation as a leading Gas Relief Capsules manufacturer, one of the 60+ products we manufacture in capsule dosage form, across 65 countries where our pharmaceutical products are distributed.

What is Gas Relief used for?

It is used to treat trapped gas (wind) in the digestive system. Simethicone is also used in the treatment of irritable bowel syndrome (IBS).

How are Gas Relief Capsules used?

This medication is manufactured to be taken orally.

What dose should be taken?

For wind, the usual dose is 140mg, as needed, 3-4 times per day. It is best to take this medication after meals and before bedtime.

Refer to a doctor or pharmacist for more specific guidelines on dosage. Do not exceed what they advise.

Why do humans take Gas Relief Capsules?

Excessive belching or eructation is due to the swallowed air or gas from carbonated beverages. Aerophagia during eating can also lead to increased gas presence. Eating, smoking, and anxiety are all conditions that might lead to gastroesophageal disorders. Supragastric belching can also lead to additional gas presence. It means expelling rapid entry of air into the esophagus.

Distention or abdominal bloating is due to aerophagia, non-ulcer dyspepsia, gastroparesis, irritable bowel syndrome, as well as organic disorders.

Intestinal bacteria are the primary source of flatus, a metabolic byproduct, with minimal contribution from swallowed air or the back-diffusion of gases, primarily nitrogen, from the bloodstream. Bacterial metabolism within the intestines produces substantial amounts of hydrogen, methane, and carbon dioxide.

All these conditions can be treated with the active ingredient from the Gas Relief Capsules. The treatment process is due to the agent Simethicone which breaks up small bubbles.

What are other indications of Gas Relief Capsules in humans?

Simethicone is the active ingredient of this drug, and it is commonly included as an adjunct in bowel preparation before colonoscopy, but there is currently no unanimous consensus on whether it should be a standard recommendation in bowel preparation protocols. Simethicone significantly increased the odds of adequate bowel preparation for single dosing but not for split dosing. Regarding patient tolerability, the addition of simethicone was linked to significantly lower odds of experiencing abdominal bloating, with no notable effects on nausea, vomiting, and abdominal pain. In terms of adenoma detection rate (ADR), although simethicone does not show a significant overall effect, studies show that single-dosing bowel preparations demonstrated a significant improvement in ADR.

Recognizing the critical role of bowel preparation quality in the success of colonoscopy, both diagnostically and therapeutically, is critical. Poor bowel preparation has been associated with increased adverse events and a reduced adenoma detection rate. Simethicone's value as an adjunct in bowel preparation stems from its detergent-like function, reducing the formation of bubbles that could hinder the visualization of the mucosa.

Are Gas Relief Capsules enough for treating some health issues?

It depends on the current health condition of the patient. The doctor should prescribe the recommended dosage for Gas Relief Capsules depending on the current health condition, patient’s age, and weight. Depending on the reason for excessive gas production, some patients might need additional treatment with anticholinergics, antacids in cases of dyspepsia and postprandial upper abdominal fullness, and additionally low doses of tricyclic antidepressants. Activated charcoal can be occasionally effective in reducing gas and mitigating unpleasant odors, though it has the drawback of staining clothing and the oral mucosa. Specialized charcoal-lined undergarments are available to address this issue. Probiotics might offer relief from bloating and flatulence by influencing intestinal bacterial flora, although data in this realm are currently limited. For individuals with confirmed bacterial overgrowth, antibiotics can be a useful intervention.

How can Gas Relief Capsules help in the treatment process of IBS?

This drug can reduce the excess gas and bloating, which might lead to less abdominal pain and normal stool.

Are Gas Relief Capsules enough for treating IBS?

Most IBS conditions require diet changes. The fiber in the diet should be increased, and patients should add supplemental fiber to improve their gut health. Dairy products should be limited to all other foods that lead to excessive gas production, including carbonated sodas and chewing gums. Patients should avoid gluten and drink enough water. Patients with IBS should also have enough activities during the day to have a full recovery faster.

Is Simethicone safe for children?

Yes, this drug, in therapeutic doses, is safe for children. The dose should be determined by a doctor, and if the children show negative side effects, the doses should be reduced, or the treatment should be stopped.

Is Simethicone safe for geriatric patients?

Simethicone is often used in older patients for colonoscopy preparation. However, there are not many studies that can confirm the safety of the drug. The doctor should decide about the prescription for older patients.

Can pregnant women use Gas Relief Capsules?

Simethicone, the active ingredient of the drug, does not enter the bloodstream, and it is only active in the gut. Pregnant women can take this medication but always following the recommendations of the doctor and gynecologist.

Is Simethicone safe during breastfeeding?

Yes, this drug does not enter the bloodstream and also does not get into the breast milk.

How should Gas Relief Capsules be stored?

This drug should be stored at room temperature, away from light and moisture, and out of reach of children. Discard any unused medication after the expiration date or if it appears cloudy or discolored.

As with all pharmaceuticals, some unwanted effects can occur from the use of Simethicone Capsules.

Serious side effects may include: • signs of an allergic reaction

The most common allergic reactions include rashes, itching, swelling, severe dizziness, and trouble breathing.

This drug usually has no side effects. If you notice any unusual side effects, contact a doctor or pharmacist.

The benefits of giving this drug should outweigh the risks.. Doctors must perform a benefit-risk evaluation before giving this drug.

For a comprehensive understanding of all potential side effects, consult a medical professional.

If any symptoms persist or worsen, or you notice any other symptoms, please call your doctor.

Before treatment, consult your doctor regarding any medications you are taking to address potential drug interactions.

Patients should inform their doctors if they are taking prescription or nonprescription medications. Other drugs in combination with this drug can increase the risk for serious side effects. Patients should not start or stop the medication or the dosage without a doctor’s approval.

Simethicone is not considered harmful for use during pregnancy and while breastfeeding but patients should inform their doctor if they are pregnant, planning to become pregnant, or are breastfeeding.

If patients are treating some chronic problem and they do not see any further improvements, they should notify their doctor.

Simethicone should be used on a regular schedule. If a dose is missed, the patient should skip to the next scheduled dose. If patients miss a dose, they should not take double doses.

This drug should be kept out of reach of children.

Systematic review and meta-analysis of randomized controlled trials of Simethicone for gastrointestinal endoscopic visibility

The main objective of this study was to evaluate the supplemental use of Simethicone in endoscopy including capsule endoscopy (CE), colonoscopy, and esophagogastroduodenoscopy. This is a systematic review and meta-analysis of randomized controlled studies on the use of Simethicone for endoscopy. During the study, the following endpoints were examined: small bowel visualization quality (SBVQ), completion rate, gastric transit time, small bowel transit time, diagnostic yield, the efficacy of bowel preparation, degree of air bubbles, and duration time.

The results from 13 studies were included and 4 studies compared the purgative or fasting plus Simethicone with purgative or fasting alone for capsule endoscopy. Patients who received supplemental simethicone before colonoscopy had a better SBVQ ([odds ratio] OR = 2.84, 95% CI: 1.74–4.65, p = 0.00). Seven studies compared purgative plus Simethicone with purgative alone for colonoscopy. Patients who received supplemental simethicone had decreased air bubbles (OR = 39.32, 95% CI: 11.38–135.86, p = 0.00).

The conclusion of the study is that supplemental simethicone improves the SBVQ and decreases air bubbles in the colonic lumen.