Fenbendazole + Rafoxanide Oral Suspension

Active Ingredients: Fenbendazole, Rafoxanide

Fenbendazole + Rafoxanide is a combination anthelmintic used to treat and control parasitic infections in livestock animals such as camels, goats, sheep, and cows. It is indicated for the treatment of infections caused by susceptible mature and immature stages of nematodes and cestodes in the gastrointestinal and respiratory tract.

This combination of two different anthelmintic agents provides a wider spectrum of parasite control. Fenbendazole is classified as a benzimidazole carbamate. It shows a broad spectrum of activity against both mature and immature nematodes and cestodes. Fenbendazole works by inhibiting glucose uptake. It binds to β-tubulin, affecting microtubule function necessary for glucose uptake. This drains a parasite's glycogen reserves, which leads to its death. This drug has the longest half-life of all benzimidazoles. Effective concentrations of the medication can be maintained for an extended period in the plasma and gut. This increases the efficacy against immature and arrested larvae and adult nematodes. This drug is especially effective in ruminants because of the slow passage in the rumen. Prolongation of contact time of the drug (2 to 3 times oral administration at 12-hour intervals) increases the drug’s efficacy and improves the bioavailability of the drug. The major route of exposure of the metabolites is through the biliary pathway and enterohepatic recycling. This drug is effective against inhibited fourth-stage larvae of Ostertagia spp.

Rafoxanide is a salicylanilide anthelmintic. This dewormer works by uncoupling the oxidative phosphorylation of flukes. It is also active against some types of roundworms and myiasis. It is not effective against tapeworms or external parasites. This drug is extensively used against fasciolosis and haemonchosis in sheep and cattle. This medication disrupts the energy metabolism of parasites and this inhibition interferes with the parasite’s ability to generate energy through phosphorylation. It is absorbed slowly and incompletely from the gastrointestinal tract after oral administration. Then, it is distributed throughout the body and reaches therapeutic concentrations at the site of the infection. It is excreted mainly through bile into feces, and small concentrations of the drug are excreted in urine.

It is important to note Fenbendazole + Rafoxanide Oral Suspension is for veterinary purposes only.

AdvaCare Pharma is a global supplier of Fenbendazole + Rafoxanide. AdvaCare excels at the production of high-quality yet cost-effective treatments for veterinary wholesale and resale sectors. This medication has been manufactured in our GMP-certified facilities located in China, India, and the USA.

AdvaCare Pharma is a GMP-certified manufacturer of Fenbendazole + Rafoxanide Oral Suspension for veterinary use. To ensure that our products meet and exceed our distributors' standards, we conduct routine internal and third-party facility inspections. As an experienced Fenbendazole + Rafoxanide manufacturer, our highly skilled team of professionals offers comprehensive support that extends throughout the entire process, including document and registration assistance.

What is Fenbendazole + Rafoxanide used for?

What animals can be treated with Fenbendazole + Rafoxanide Oral Suspension?

This medicine is recommended for livestock like camels, cows, goats, sheep, and pigs.

How is Fenbendazole + Rafoxanide Oral Suspension used?

This medicine has been manufactured as a liquid suspension, which is intended to be administered orally.

Is only this Fenbendazole + Rafoxanide Oral Suspension enough to treat a parasitic infection?

It depends on the cause of the parasitic infection and the animal’s response. In some mild cases, only this antiparasitic drug can help in the treatment process.

How does Fenbendazole + Rafoxanide Oral Suspension help animals?

Studies show that treating helminth parasites with Fenbendazole resulted in improved weights of accessory sex glands, testes, and epididymis indices. It increased white blood cell count, hemoglobin levels, packed cell volume, serum protein, albumin-globulin ratio, serum urea, and serum creatinine levels compared to treatment with rafoxanide alone or their combination. However, Fenbendazole treatment decreased sperm motility and sperm count and led to higher sperm abnormalities compared to rafoxanide treatment. Rafoxanide treatment improved sperm motility and count and reduced the percentage of abnormalities compared to Fenbendazole or their combination. Histopathological analysis revealed more severe histological changes in the groups treated with Fenbendazole and rafoxanide than in the control group or their combination treatment.

Rafoxanide is efficient against almost all mature and most immature (6 week old) Fasciola hepatica and Fasciola gigantica, adult Haemonchus species in cattle and sheep, and the parasitic larval stages of sheep nasal bot are susceptible. It is also active against gastrointestinal nematodes (Haemonchus, Bunostomum, Oesophagostomum, and Gaigeria species) and against the sheep nasal bot fly (Oestrus ovis).

Fenbendazole, a benzimidazole anthelmintic, undergoes metabolism in mammals to produce various benzimidazoles, including oxfendazole. It is widely used to control gastrointestinal roundworms, lungworms, and tapeworms. Fenbendazole is recognized and approved by the European Agency for the Evaluation of Medical Products (EMEA) for its effectiveness in treating and preventing pinworm infections. Specifically approved for use in swine, it targets parasites such as Ascaris, Trichuris, Oesophagostomum, Strongyloides, and Hyostrongylus spp.

Combining Rafoxanide with other anthelmintics improves its efficacy in combating gastrointestinal parasites.

How to check if the treatment with Fenbendazole + Rafoxanide Oral Suspension is successful?

Regular fecal egg count reduction tests need to be performed to check if the treatment procedure has been successful. Animals often develop resistance to certain drugs. In that case, other drugs need to be included in the treatment of the animals.

Is Fenbendazole + Rafoxanide Oral Suspension effective in the treatment of bacterial infection?

No, this is a drug that is effective only in the treatment of parasitic infections. In cases of bacterial infections, antibiotics need to be included.

Can Fenbendazole + Rafoxanide Oral Suspension be used for treating viral infections?

No, this drug is not effective in the treatment procedure of viral infections. In cases of viral infections, antiviral drugs, vitamins, and other supplements need to be included.

What should be done if a dose is missed?

If a dose of this drug is missed, the next scheduled dose needs to be given. Do not give double doses of this drug.

How should Fenbendazole + Rafoxanide Oral Suspension be stored?

This medication should be stored in a dark, dry location under 25°C. Keep this drug out of reach of children and pets.

Is there a withdrawal period after treatment with Fenbendazole + Rafoxanide?

The withdrawal period is 60 days for meat. The exact duration will depend on local regulations.

How much Fenbendazole + Rafoxanide Oral Suspension should be given to cows?

The dose should not exceed 1.25ml per 50kg of body weight.

How much Fenbendazole + Rafoxanide Oral Suspension should be given to sheep?

The dose should not exceed 1.5ml per 10kg of body weight.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Fenbendazole + Rafoxanide Oral Suspension.

Serious side effects may include: • allergy or hypersensitivity reactions

If any side effects arise, they should be reported immediately to a veterinary professional and be treated accordingly. Side effects usually occur in cases of overdose. The veterinarian should perform a throughout exam and decide about the dosage.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

If a dosing gun is being used, be careful not to injure the mouth or pharynx of the animal.

This medication should be used with caution because resistance might occur. Parasite management practices need to be appropriate according to the geographic area and the animals’ current health condition.

Regular fecal examinations and other diagnostic tests need to be performed to determine whether the treatment is suitable for the animal. The effectiveness of the treatment can be monitored by conducting a fecal egg count reduction test or other available methods. The further treatment procedure needs to be adjusted on the results from the regular monitoring.

Always wash your hands after using this drug. Pregnant women should not handle this medication, as it can be absorbed through direct skin contact.

Fenbendazole + Rafoxanide Oral Suspension is mainly used to treat stomach worms, lungworms, tapeworms, and mature and immature fluke.

Ruminant Animals Parasitic Infections

In cows, goats, and sheep, Fenbendazole + Rafoxanide Oral Suspension can help in the treatment process of major adult gastrointestinal parasites and many of the larval stages. The metabolism and excretion are mostly extensive in cattle, but the systemic anthelmintic activity is greater in sheep. This medication is effective in the treatment of Ostertagia spp., Dictyocaulus viviparus, Fasciola hepatica, and Moniezia spp. in sheep and cattle.

Pig Parasitic Infections

This medication can be used for treating both adult and immature stages of Ascaris suum. This drug is highly effective against most swine nematodes.