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Prednisone Tablets
Dosage
Packaging
What is Prednisone?
Active Ingredients: Prednisone
Prednisone Tablets are a steroid drug used to treat conditions that are associated with inflammation, like arthritis, asthma, and autoimmune disorders. It is also used to treat blood or bone marrow disorders, breathing problems, severe allergies, skin diseases, vision problems, and adrenal gland diseases.
This medication is used in combination with other anticancer drugs in the treatment of acute lymphoblastic leukemia, non-Hodgkin's lymphoma, Hodgkin's lymphoma, multiple myeloma, and other hormone-sensitive tumors.
Prednisone is a synthetic corticosteroid. It works by decreasing the immune system's response to various diseases, which reduces symptoms such as swelling and allergic-type reactions.
AdvaCare Pharma is a GMP-certified producer and exporter of Prednisone Tablets. We offer a wide range of high-quality and cost-effective medical products that are available for distribution. These medications have been manufactured in our facilities in China, India, and the USA.
Why are we a top Prednisone manufacturer?
AdvaCare Pharma is a trusted Prednisone manufacturer committed to providing quality-assured, cost-effective pharmaceuticals for an ever-changing global market. Manufacturing a wide range of 200+ pharmaceutical products in tablet form, we ensure that all of our oral solid dosage forms adhere to stringent GMP standards.
We operate according to a unique "vested supplier-distributor relationship" business model, in which we tie our success in a market to that of our distributor. Such a model facilitates a closer relationship by working together to achieve pre-defined goals for market entry and expansion. As a Prednisone manufacturer and global supplier, we implement unique strategies to ensure successful distribution.
Uses
What is Prednisone used for?
It is used to reduce inflammation and lower an overactive immune system. It is used in the treatment of a variety of conditions, such as:
- severe allergies
- skin conditions
- autoimmune disorders
- blood or bone marrow disorders
- breathing problems
- cancer
- vision or eye problems
How should Prednisone Tablets be used?
This medication is intended to be taken orally. Prednisone Tablets should be taken after a meal.
What dose should be taken?
Recommended dosage may vary based on different medical conditions.
Adult Dosing Dosage may vary based on different medical indications:
- For corticosteroid-responsive conditions, the usual dose is 5-60mg per day. The exact dose and frequency vary by condition. When discontinuing high-dose or long-term use, it is important to taper the dose gradually.
- For adrenal insufficiency, the usual dose is 4-5mg/m^2 per dose, taken once daily.
- For acute exacerbation of multiple sclerosis, the usual dose is 1250mg, taken once per day. The duration of treatment is 3-5 days.
- For acute asthma, the usual dose for ED or hospital management is 40-80mg per day, divided and taken once or twice. Continue treatment until a peak flow rate of 70% is met. For outpatient burst treatment, the usual dose is 40-60mg per day, divided and taken once or twice. Treatment should continue for 3-10 days.
- For severe persistent asthma, the usual dose is 7.5-60mg, taken once per day or every other day. When discontinuing high-dose or long-term treatment, the dose should be gradually tapered.
- For acute gout, the usual dose is 0.5mg/kg per day. The duration of treatment is 5-10 days.
- For chronic obstructive pulmonary disease (COPD) exacerbation, the usual dose is 40mg, taken once a day for 5 days.
- For acute alcoholic hepatitis, the usual dose is 40mg, taken once per day. The dose should be gradually tapered when discontinuing treatment.
- For a type 1 leprosy reaction (reversal reaction), the usual dose is 1mg/kg per day, divided and taken once or twice a day. The duration of treatment is 12 weeks. Alternatively, 40-60mg per day, divided and taken once per day. For severe reactions, treatment may continue for 3-9 months.
- For a type 2 leprosy reaction (erythema nodosum leprosum), the usual dose is 1mg/kg per day, divided and taken once or twice a day. Alternatively, 40-60mg, divided and taken once or twice per day. Treatment can be combined with thalidomide in the event of moderate to severe neuritis. Clofazimine can also be prescribed in severe refractory cases. Treatment should be reassessed every other week.
- For the adjunct treatment of pneumocystis pneumonia (PCP), the usual dose is 40mg, taken twice per day for 5 days. Then dosage is reduced to 40mg for 5 days, and 2mg for 11 days.
- For primary focal segmental glomerulosclerosis, the usual dose is 1mg/kg per dose, taken once per day for 4-16 weeks. To discontinue, taper dose by 5mg per day for 1-2 weeks. The duration of treatment should be 6 months total.
Pediatric Dosing Recommended dosage for children may vary based on different medical conditions:
- For corticosteroid-responsive conditions, the usual dose is 0.05-2mg/kg per day, divided and taken between 1-4 times per day. The exact dose and frequency vary by condition. When discontinuing high-dose or long-term treatment, the dose should be gradually tapered.
- For acute asthma, the usual dose for ED or hospital management is 1-2mg/kg, per day, divided and given once or twice. Continue treatment until a peak flow rate of 70% is met. For outpatient burst treatment, the usual dose is 1-2mg/kg per day, divided and taken once or twice. Treatment should continue for 3-10 days.
- For severe persistent asthma, the usual dose is 0.25-2mg/kg, divided and taken once per day or every other day. The maximum dosage is 60mg/day. When discontinuing high-dose or long-term treatment, the dose should be gradually tapered.
- For adrenal insufficiency, the usual dose is 4-5mg/m^2 per dose, taken once each day. The dose should be gradually tapered when discontinuing treatment.
- For nephrotic syndrome, the usual dose is 60mg/m^2 per day, divided and taken once or twice each day. Treatment should continue for 4-6 weeks, and then the dose should be reduced to 40mg/m^2 per dose, taken every other day for 4-6 weeks.
- For infantile hemangioma, the usual dose is 2-3mg/kg, per dose, given once per day. The dose should be gradually tapered at the end of treatment.
For the adjunct treatment of pneumocystis pneumonia (PCP), the usual dose for children is as follows:
- Children < 40kg: 1mg/kg, given twice a day for 5 days. Then the dose should be reduced to 0.5mg/kg, taken twice per day for 5 days. Then the dose should be further reduced to 0.5mg, taken once per day for 11 days. Treatment should begin within 72 hours of antimicrobial medication.
- Children > 40kg and adolescents: 40mg, taken twice each day for 5 days. The dose is then reduced to 30mg, twice per day for 5 days. The dose is further reduced to 20mg once per day for 11 days. Treatment should begin within 72 hours of antimicrobial medication.
The dosage is based on medical condition, response to treatment, age, and weight. Refer to a doctor or pharmacist for guidelines on dosage. Do not exceed what they advise.
Who can use Prednisone?
Prednisone Tablets can be taken by adults and children, but caution is advised for specific groups of patients.
Pregnant Prednisone should only be prescribed if the benefits outweigh the risks, particularly in the 1st semester or for long-term treatment. There is a possible risk of orofacial cleft, but there are conflicting human data and animal data available. Possible risk of low birth weight and premature birth based on limited human data. There is also a possible risk of fetal adrenal suppression, based on the drug's mechanism of action.
Breastfeeding Prednisone can be used while breastfeeding. During prolonged high-dose treatment, breastfeeding should be avoided 4 hours after dosing. There are no known risks of infant harm based on the limited human data available. There is a possible risk of suppressed growth and endogenous steroid production due to the drug's mechanism of action.
Children The long-term usage of steroids has been associated with growth suppression in pediatric patients. Children should be closely monitored by healthcare providers during treatment. It may be necessary to regularly assess growth, bone density, and other factors in order to minimize the impact on growth.
Geriatric Bone mineral density (BMD) should be monitored during prolonged treatment in patients older than 65 years. Calcium and vitamin D supplementation or other interventions may be necessary.
Other warnings
During treatment, electrolytes, blood pressure, and weight should be monitored.
Steroids are known to increase glucose levels in blood and urine. Diabetic medications may need to be adjusted for patients with diabetes.
This medication increases the risk of stomach ulcers or gastrointestinal bleeding. It may be necessary to schedule an upper GI x-ray under medical discretion if a patient presents with symptoms of an ulcer or significant dyspepsia.
Side Effects
As with all pharmaceuticals, some unwanted effects can occur from the use of Prednisone Tablets.
Common side effects include, but may not be limited to:
- headache
- dizziness
- inappropriate happiness
- changes in mood or personality
- thinning skin
- extreme tiredness
- heartburn
- decreased sexual desire
Serious side effects may include:
- changes in vision or eye pain
- signs of infection
- seizures
- depression or confusion
- irregular heartbeats
- sudden weight gain
- signs of an allergic reaction
Long-term usage of steroids is associated with reactions such as impaired wound healing, skin atrophy, and Cushing syndrome. The risk of osteoporosis, glaucoma, cataracts, immunosuppression, and Kaposi sarcoma are also associated with long-term usage.
For a comprehensive understanding of all potential side effects, consult a medical professional.
If any symptoms persist or worsen, or you notice any other symptoms, please call your doctor immediately.
Precautions
Do NOT use Prednisone Tablets if:
- You are allergic to any of the ingredients.
- You are pregnant or breastfeeding.
- You are having surgery or need emergency medical treatment.
Prednisone may not be suitable for people with certain conditions, so it is important to consult with a doctor if:
- You have an illness that causes diarrhea.
- You have heart disease, high blood pressure, or low levels of potassium.
- You have tuberculosis, osteoporosis, diabetes, a history of malaria, stomach ulcers, or ulcerative colitis.
- You have a muscle disorder such as myasthenia gravis.
- You have depression or any other mental illness.
- You are missing certain vaccinations.
- You have recently been exposed to chickenpox or measles.
Before treatment, consult your doctor regarding any medications you are taking to address potential drug interactions.Treatment with prednisone is contraindicated with live vaccines (e.g. adenovirus vaccine, cholera vaccine, dengue vaccine, influenza vaccine), talimogene laherparepvec, mifepristone, and desmopressin. Some known drug interactions include cortisone, dexamethasone, contraceptives, furosemide, and prednisolone.
Grapefruit products should be avoided during treatment.
References
Low-Dose Prednisone Therapy for Patients with Early Active Rheumatoid Arthritis: Clinical Efficacy, Disease-Modifying Properties, and Side Effects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
This study aimed to assess the clinical efficacy, disease-modifying effects, and side effects of low-dose glucocorticoids as a standalone treatment for newly diagnosed patients with early active rheumatoid arthritis.
It is a 2-year randomized, double-blind, placebo-controlled clinical trial conducted at two outpatient rheumatology clinics that included a total of 81 patients with early active rheumatoid arthritis who had not previously received treatment with disease-modifying antirheumatic drugs. Forty-one patients were assigned to receive 10mg of oral prednisone daily, while 40 were assigned to receive placebo. Both groups were allowed to use nonsteroidal anti-inflammatory drugs. After 6 months, sulfasalazine (2g/day) could be prescribed as rescue medication.
During the initial 6 months, the prednisone group demonstrated greater clinical improvement compared to the placebo group. After the 6-month mark, radiologic progression was significantly reduced in the prednisone group compared to the placebo group.
The conclusion of this study is that a daily dose of 10mg prednisone provides clinical benefits, especially during the initial 6 months, and effectively inhibits the progression of radiologic joint damage in patients with early active rheumatoid arthritis.
Why AdvaCare Pharma?
As an industry leader, we are aware of our responsibility to provide affordable and sustainable solutions to improve healthcare worldwide.