Colistin Sulfate Soluble Powder

Active Ingredients: Colistin Sulfate

Colistin Sulfate Soluble Powder is an antibiotic drug used to treat infections in livestock animals like cows, sheep, pigs, and poultry. It is indicated for intestinal infections and diseases like scour, piglet paratyphoid, colibacillosis, and pullorum disease. This drug is typically absorbed in the gastrointestinal tract of an animal.

Colistin is also known by the name polymyxin E. It works by interfering with and breaking down the cell membrane of the bacteria. Colistin shows bactericidal activity against many gram-negative microorganisms, including Aerobacter aerogenes, Escherichia coli, Salmonella, Shigella, Haemophilus, Pasteurella, Pseudomonas aeruginosa, and Vibrio.

Colistin's mechanism of action disrupts the integrity of the bacterial cell membrane, leading to leakage of cellular components and ultimately causing cell death. This bactericidal activity against a wide range of gram-negative microorganisms makes colistin an important antibiotic in the treatment of infections when other options are limited due to antibiotic resistance.

While it primarily targets gastrointestinal infections in livestock, note that colistin is often reserved for situations where other antibiotics have proven ineffective or when no suitable alternative is available, as its use can contribute to antibiotic resistance in bacterial populations. Proper dosing and veterinary supervision are essential to ensure its judicious and responsible use in animal health.

This product is available in packaging sizes such as 50g and 100g bags for smaller-scale applications and 500g bottles, 1kg bags, and 5kg bags for larger herds or longer treatment durations.

Colistin Sulfate Soluble Powder is a GMP-certified product that has been manufactured by AdvaCare Pharma. This medication is a part of our catalog of veterinary supplies available for global distribution. Our manufacturing facilities are located in China, India, and the USA.

Colistin Soluble Powder is manufactured and globally supplied by AdvaCare Pharma. Our comprehensive range of 250+ GMP-certified veterinary medicines are adapted to meet the specific market needs and demands of our veterinary distributors. Equipped with an expert regulatory affairs team and advanced production capabilities, we are a Colistin manufacturer with production capacity to manufacture more than 70 oral powder formulations that are cost-effective, efficacious and market-adapted for vet distributors, veterinarians and farmers worldwide.

What is Colistin Sulfate used for?

What animals can be treated with Colistin Sulfate Soluble Powder?

This medicine is recommended for poultry, cows, sheep, and pigs.

Is Colistin Sulfate effective against all bacterial infections in animals?

Colistin sulfate is primarily effective against Gram-negative bacteria. It may not be effective against infections caused by gram-positive bacteria or certain resistant strains. A susceptibility test is recommended before use.

How is Colistin Sulfate Soluble Powder used?

This medicine has been manufactured as a powder, which is intended to be diluted and administered orally. To prepare the medication, the prescribed quantity of powder is mixed with a specific volume of clean, fresh water according to recommended dilution ratios. Monitoring water consumption is vital to guarantee that animals receive the correct dosage. Treatment typically lasts for 3-5 days, but the duration may vary depending on the specific condition. Medicated water should be discarded after use.

Is there a withdrawal period after treatment with Colistin Sulfate?

The withdrawal time is 7 days for poultry and swine. Meat or products from animals treated with this drug should not be consumed until the withdrawal period is completed to ensure that residue levels are within safe limits for human consumption.

Can Colistin Sulfate Soluble Powder be used in combination with other antibiotics?

Colistin sulfate can be used in combination with other antibiotics, but the choice of combination therapy should be made based on the specific infection and under the guidance of a vet.

Can Colistin Sulfate be used for prophylactic purposes or only for treatment of existing infections?

It is mainly intended for the treatment of bacterial infections. Its prophylactic use should be considered only under specific circumstances and with veterinary guidance to minimize the risk of antibiotic resistance.

Can Colistin Sulfate Soluble Powder be used for pregnant or lactating animals?

Colistin sulfate should be used cautiously in pregnant or lactating animals, as its safety during these conditions has not been extensively studied. Consult a veterinarian for guidance in such cases.

Is there a risk of developing antibiotic resistance with the use of Colistin Sulfate in animals?

The use of colistin sulfate in animals can contribute to antibiotic resistance. It should be used judiciously, following veterinary guidance, to minimize the risk of resistance development.

Is Colistin Sulfate available over-the-counter or does it require a prescription?

It is typically available by prescription from a veterinarian. It should be used under professional guidance to ensure proper diagnosis, dosage, and treatment duration.

Can Colistin Sulfate be used in food-producing animals intended for export or international trade?

Regulations regarding the use of colistin sulfate in food-producing animals may vary by country. Consult with local veterinary authorities and comply with international trade regulations to ensure the safety and legality of animal products intended for export.

Is there any difference in the formulation or quality of Colistin Sulfate Soluble Powder between the various packaging sizes?

No, the formulation and quality remain consistent across different packaging sizes. The only variation lies in the quantity of product contained in each package.

How should Colistin Sulfate Soluble Powder be stored?

This medication should be stored in a dark, dry location between 2-25°C. Keep the packages sealed tightly when not in use.

How much Colistin Sulfate Soluble Powder should be given to swine?

The usual dose is 100mg per 100L of drinking water. The duration of treatment is 3-5 days.

How much Colistin Sulfate Soluble Powder should be given to poultry?

The usual dose is 750g per 1000kg of feed. The duration of treatment is 3-5 days.

What should be done if an animal misses a dose of Colistin Sulfate?

If an animal misses a dose, do not double the next dose. Continue with the regular dosing schedule, and consult a veterinarian if necessary.

What should be done in case of an overdose of Colistin Sulfate Soluble Powder?

Seek immediate veterinary assistance. Overdosing can lead to potential adverse effects, including increased risk of toxicity and adverse reactions. A veterinarian will assess the situation, provide appropriate supportive care, and recommend interventions, such as symptomatic treatment or fluid therapy.

Is it necessary to calculate the total water consumption for a group of swine when administering Colistin Sulfate in drinking water?

Yes. This can be achieved by measuring the water intake of a representative sample of swine over a specific period, which can then be used to calculate the total daily water consumption for the entire group. The dosage should be adjusted accordingly to achieve the desired concentration in the water. Veterinary guidance can help ensure accuracy in this process.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Colistin Sulfate Soluble Powder.

Some common side effects may include but are not limited to gastrointestinal effects, such as diarrhea, vomiting, and decreased appetite. Maintain proper hydration and nutrition for animals experiencing these side effects.

In all cases of suspected side effects, call a veterinarian immediately for assessment and appropriate management. Medication should not be continued if serious side effects are observed, and alternative treatment options should be discussed with a qualified veterinary professional.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

Exercise caution when administering colistin sulfate to animals with impaired renal function, as this drug is primarily excreted through the kidneys. Regular monitoring of renal status may be necessary in such cases to prevent potential drug accumulation and toxicity.

When handling Colistin Sulfate Soluble Powder, appropriate protective measures should be taken to prevent contact with skin, eyes, or inhalation of the powder. Use personal protective equipment when preparing and administering.

Do not continue treatment with this drug past one week.