Oxytetracycline HCl Soluble Powder

Active Ingredients: Oxytetracycline HCl

Oxytetracycline HCl Soluble Powder is an antibiotic water additive used to treat a wide variety of bacterial diseases in cows, poultry, goats, pigs, and sheep. In cattle, it is indicated for the treatment of infections such as pneumonia, shipping fever, foot rot, diphtheria, and bacterial enteritis.

Oxytetracycline HCl is a broad-spectrum antibiotic in the tetracycline family. It is derived from the fermented product of Streptomyces rimosus. Oxytetracycline works by inhibiting protein synthesis in the bacteria. It is active against both gram-positive and gram-negative bacteria, including Mycoplasma pneumoniae, Diplococcus pneumoniae, and Escherichia coli. It also shows action against Chlamydia, Rickettsia, and spirochetes.

Upon oral administration, the antibiotic is absorbed in the upper small intestine and distributed throughout the bloodstream within 2-4 hours. Factors like sodium bicarbonate, aluminum hydroxide, calcium, iron, and dairy products can influence the absorption process.

The antibiotic quickly permeates the entire body, achieving high concentrations in various tissues and fluids, including the kidneys, liver, spleen, bone, bile, and lungs. Biotransformation in domestic animals is limited, and the drug is excreted without alteration. Excretion takes place through both glomerular filtration and the gastrointestinal tract, with factors like the animal's age, route of administration, renal health, urine pH, and glomerular filtration rate influencing the process.

Regardless of the chosen administration method or form, oxytetracycline is widely distributed and sequestered in the animal's body, particularly in the liver, kidney, bone, and dentine. Tetracyclines undergo minimal metabolism in animals, and the drug is excreted unchanged through urine. It is advisable to conduct blood tests and urinalysis before initiating antibiotic treatment rather than during the treatment period.

This antibiotic is also available in form of tablets, bolus, injection, premix, and soluble powder. The chosen form depends on the veterinarian and the current health condition of the animal.

It is important to note that this formulation of oxytetracycline is for veterinary purposes only.

AdvaCare Pharma is a trusted exporter of Oxytetracycline HCl Soluble Powder. This veterinary medication is produced in our GMP-certified manufacturing facilities in China, India, and the USA.

Oxytetracycline Soluble Powder is manufactured and globally supplied by AdvaCare Pharma. Our comprehensive range of 250+ GMP-certified veterinary medicines are adapted to meet the specific market needs and demands of our veterinary distributors. Equipped with an expert regulatory affairs team and advanced production capabilities, we are an Oxytetracycline manufacturer with production capacity to manufacture more than 70 oral powder formulations that are cost-effective, efficacious and market-adapted for vet distributors, veterinarians and farmers worldwide.

What is Oxytetracycline HCl used for?

What animals can be treated with Oxytetracycline HCl Soluble Powder?

This medicine is recommended for poultry and livestock animals like cows, goats, pigs and sheep.

How is Oxytetracycline HCl Soluble Powder used?

This medicine has been manufactured as a water-soluble powder for oral administration.

How can Oxytetracycline HCl Soluble Powder help animals?

The specific diseases treated with oxytetracycline depend on the animal species. In cattle, it is primarily used against Pasteurella multocida, Mannheimia haemolytica, and Histophilus somni (Bovine Respiratory Disease). For pigs, it is employed to combat Mycoplasma infections, pneumonic pasteurellosis, and atrophic rhinitis. In companion animals, it is commonly used for Rickettsia spp. and Ehrlichia spp. Infections.

How does Oxytetracycline help in managing Mycoplasma infections?

Animals with weakened immune systems and those residing in unhygienic housings often experience Mycoplasma infections. These infections, induced by gram-negative bacteria without a cell wall, can result in various complications affecting the gastrointestinal, respiratory, and reproductive systems. Oxytetracycline, known for its effectiveness against bacteria lacking a cell wall, stands as the preferred treatment for Mycoplasma infections, requiring a two-week administration period.

How should Oxytetracycline HCl Soluble Powder be stored?

This medication should be stored in a dark, dry location under 30°C.

What is the withdrawal period for Oxytetracycline HCl?

For meat, the withdrawal period is 28 days. The withdrawal time is 24-72 hours for milk.

How much Oxytetracycline Soluble Powder should be given to livestock?

The usual dose is 5g per 1000 kg body weight dissolved in water, twice daily for 2 or 3 days.

How much Oxytetracycline Soluble Powder should be given to poultry?

The usual dose is 1tsp per gallon of water. Treatment continues for 5 to 7 consecutive days. The dosage can vary depending on the species of poultry and the severity of the infection.

The dosage is contingent on the current health condition of the animal, and it is determined by a veterinary examination. Additionally, the dose is influenced by the age and body weight of the animal.

Refer to a veterinary doctor or pharmacist for guidelines on dosage.

As with all pharmaceuticals, some unwanted effects can occur from the use of Oxytetracycline HCl Soluble Powder.

Serious side effects may include: • allergic reaction

Excessive oral doses may cause a decrease in microflora or ruminoreticular stasis in ruminants.

The use of tetracycline antibiotics in animals can lead to superinfections caused by fungi, yeast, and resistant bacteria.

Critically ill animals may experience gastrointestinal disturbances, including vomiting, diarrhea, and constipation, following oral consumption. Allergic reactions, such as itching, difficulty breathing, and swelling, should prompt immediate professional assistance.

Higher-than-recommended antibiotic dosages may induce neuromuscular blocking effects.

It is not recommended to use tetracyclines for animals with botulism, as they already have neuromuscular blockage, and the administration of tetracyclines could worsen their condition.

Oxytetracycline has the potential to chelate calcium in teeth and bones, resulting in yellow or brown discoloration. Excessive and frequent dosages may lead to the fracture of the animal’s teeth.

Animals with liver issues should undergo examination before receiving oxytetracycline due to potential hepatotoxic effects, especially in pregnant animals with a higher mortality rate.

In animals with renal insufficiency, the administration of oxytetracycline may lead to nephrotoxic effects.

For a comprehensive list of all possible side effects of this medication, consult a veterinarian.

This medication has the potential to lead to inaccurate results in urine catecholamine readings and may cause a false-positive outcome for urine glucose when Benedict's reagent is used.

Additionally, since the drug is eliminated through feces, it may not be the most suitable choice for animals dealing with chronic gastrointestinal issues.

Oxytetracyclines should be avoided in pregnant and lactating animals because the drug is excreted in milk, and traces of the medication can persist for up to 48 hours.

Prior to prescribing oxytetracyclines, it is recommended for a veterinarian to evaluate patients with chronic kidney disease. This is crucial as biotransformation and excretion primarily occur in the kidneys, and patients with low glomerular filtration may be affected.

The effectiveness and absorption of tetracyclines may decrease when taken with dairy products.

The antibiotic's activity can be compromised if it is diluted in fluids and exposed to ultraviolet light.

Keep the drug out of reach of children and animals.

Poultry Bacterial Infections

Oxytetracycline is employed to address severe bacterial infections in poultry, including Mycoplasma infections in the respiratory tract caused by susceptible bacteria. Avibacterium paragallinarum can also be managed with oxytetracycline. In cases of Pasteurella multocida or Fowl Cholera, a combination of antibiotics and supplements can be utilized for poultry treatment. Oxytetracycline demonstrates effectiveness against various enteric infections in poultry.

Ruminants (Cow, Goat, and Sheep) Bacterial Infections

Oxytetracycline in ruminants is used for treating severe bacterial infections. This includes treating cattle from the Bovine Respiratory Disease caused by very pathogenic bacteria. It can also help in other respiratory infections as well as soft tissue infections. Mycoplasma infections can also be addressed with this antibiotic.

Pig Bacterial Infections

In pigs, this antibiotic can help in the treatment of Atrophic rhinitis, as well as many gram-negative and gram-positive infections. This antibiotic is also a good choice in the treatment of enteritis caused by E. coli.

Veterinarians determine the drug of choice depending on the antibiogram results, the animal’s species, age, and body weight. Some of the previously mentioned diseases and conditions need to be supplemented with other drugs, vitamins, and minerals.